Dapagliflozin, Sitagliptin, and Metformin Tablets

Dapagliflozin, Sitagliptin, and Metformin Tablets are available with the brand name “SUGRIP-DM 500” and are an antidiabetic drug prescribed to treat Type II Diabetes. In type 2 diabetes, the pancreas cannot secrete adequate insulin, or the body cannot utilise insulin properly. Due to this, blood sugar increases. 

Dapagliflozin, Sitagliptin, and Metformin Tablets include Dapagliflozin, Sitagliptin, and Metformin. It operates by eliminating unwanted sugar from the body via urine, raising the concentrations of specific natural compounds that reduce blood sugar when elevated, decreasing sugar release by cells in the liver, and slowing down sugar absorption from the intestines.  

Uses

• Type 2 Diabetes Control: It is applied to enhance blood sugar control in individuals with type 2 diabetes. It combines three agents that synergistically decrease glucose production, increase insulin sensitivity, and increase glucose excretion via the urine.
• Cardiovascular and Kidney Guard: It aids in lowering the risk of heart failure and diabetic kidney disease by enhancing vascular function, decreasing albuminuria, and maintaining healthy blood pressure.
• Weight and Metabolic Control: It aids in weight reduction and metabolic well-being by lowering surplus glucose and increasing insulin sensitivity, thus being helpful for obese or overweight diabetic patients.
• Reduction in HbA1c and Glycemic Control: The tablet successfully reduces HbA1c and sustains normal blood sugar levels during the day, preventing hypoglycemia and long-term microvascular complications.

Medical Benefits

• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that assists in the increase of insulin release and reduction of glucagon levels in the body, reducing blood sugar levels during their elevation.
• Please note that dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, functions by flushing out excess glucose from the body through urine, thus reducing blood sugar levels.
• Metformin is a biguanide that lowers the liver’s production of sugar and slows down glucose intake from the intestine.  
• It enhances the sensitivity of the body to insulin, enhancing the uptake of glucose by muscles and tissues.  
• The triple action of these three drugs provides multi-targeted regulation of blood sugar, particularly in single or dual therapy non-controlled patients. 
• It maintains control over blood glucose levels and avoids diabetes complications such as eye disease, nerve damage, and kidney disease. 

Directions for Use

• Take this drug with food to minimise stomach irritation.
• Use your doctor’s instructions on the timing and dosage of this medication.
• Take Dapagliflozin, Sitagliptin, and Metformin Tablets whole with water.
• Do not chew, crush, or break it.

Storage

• Adhere to thе storagе instructions еndlеssly еndеd on thе mеdication’s packagе.
• Ensure thе mеdication remains out of thе rеach of childrеn and pеts.
• Store thе tablеts at rоom tеmpеraturе.
• Keep it away from еxcеssivе hеat, moisturе, and light.
• Rеad thе spеcific storagе guidеlinеs еndlеssly еndеd with thе prеscription or as instructed by thе pharmacist.

Precautions

• It may interact with antidepressants (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), medications for heart conditions (digoxin), and anti-epileptic drugs (topiramate, lamotrigine).
• Consuming large amounts of alcoholic drinks may increase the likelihood of a potentially fatal condition called Lactic Acidosis. Therefore, avoid its consumption along with this medicine.
• Inform your physician in case you have any liver or kidney disease or heart disease.
• Dapagliflozin, Sitagliptin, and Metformin Tablets should not be generally used during breastfeeding.
• This combination should not be used by children younger than 18 years. Take the doctor’s advice before giving it to the child.

Side Effects

• Vomiting
• Abdominal pain
• Nausea
• Headache
• Stomach upset

Frеquеntly Askеd Quеstions (FAQs)

Can kidney patients take this tablet?

Yes, only if the kidney issue is mild and under a doctor’s supervision.

Is it safe for heart patients?

Yes, it can be useful for heart failure patients, but with a doctor’s recommendation.

Can Type 1 diabetics use it?

No, it is not intended for Type 1 Diabetes or diabetic ketoacidosis.

Can it be used with insulin?

Yes, but the dose of insulin should be adjusted to prevent low blood sugar.

Does it aid in losing weight?

Yes, it can cause minimal weight loss by eliminating excess sugar in urine.

Can pregnant or lactating women use it?

No, not during pregnancy or lactation.

Do I have to eat a special diet?

Yes, eat a balanced, low-sugar diet for optimal results.